M.Pharmacy Old Question Paper – April 2016 (Novel Drug Delivery Systems II)

1 (a) Explain the role of any two physiological factors affecting oral bioavailability of drugs with examples.

(b) Enumerate various transport mechanisms across the cell membrane. Add a note on efflux transporter systems.

2 (a) What are “m cells and peyer’s patehes in GIT? Explain their significance.

(b) Explain in brief about the lymphatic transport of drugs.

3 (a) what is gene therapy? What are potential target diseases for gene therapy? Add a note on gene expression system.

(b) Explain the bio-distribution and pharmacokinetics of liposomal gene delivery systems.

4 (a) Define genomics, proteomics and bio-informatics. Write in brief about human genome project.

(b) Outline the gene therapy for hepatitis  and AIDs.

5 (a) What are the difficulties and challenges in the delivery of biotechnology based drugs?

(b) Explain about DNA technology for engineered proteins with an example.

6 (a) What is immunization? Explain various types of it.

(b) Explain the development of single dose vaccine delivery systems using biodegradable polymers.

7 (a) Explain various types of drug targeting with examples.

(b) Discuss in brief about molecular basis of drug targeting.

8 Write note on:
(a) Exvivo and Invivo gene therapy
(b) Micro particles for vaccine delivery
(c) Recombinant proteins