M.Pharmacy Previous Papers – Bio pharmaceutics and Pharmacokinetics

1.  Write about briefly formulation factors affecting bioavailability of drugs like solids, patentrals and liquid dosage forms Note on in-vivo methods.

2. Describe about regulations, types, requirements needed for bioequivalence studies Design. Add account on invitro –  in vivo comparison.

3. (a) Explain about physiologically induced time-dependent pharmacokinetics

(b) Write short notes on individualization of therapeutic drug monitoring.

4. (a) Discuss about linear and non linear pharmacokinetics.

(b) Determine the Michaelis Mentan equations and its application.

5. (a) Discuss about clinical pharmacokinetics affect on liver and renal disease states.

(b) Discuss dosage adjustment in renal and hepatic impairment accumulation index

6. Write about:
(a) Physico chemical properties affecting bioavailability

(b) partition theory and surface area adsorption

7. Enumerate about one and two compartment models approaches to pharmacokinetic studies, Add note on Auc and its

8. Write short notes on:
(a) Tests of significance.
(b) Metabolic rate constant
(c) Concept of clearance and types
(d) Non invasive methods for estimation of pharmacokinetic studies